Hi @crankyyankee, I don't have any experience with Crestor and Zetia but did a quick search of Connect at the top of the page and found the following members who may be able to share their experience using Zetia with Crestor. @markdeegan @helpfull @ihaq1 @hmccarth5 @jlharsh and @keithl56 have posted about using Zetia along with Crestor in other discussions and hopefully can share their experience with you.