I have seen many on here who split the dose with success; even considered it myself. Rheumatologists in general want us to follow "their schedule". Mine does this as well, but her schedule is not working for my body. Listen to your body. Don't decrease too quickly, as John mentioned. I too am considering shopping around, but waited a long time (5.5 months) to see her. She doesn't want to see me again for 4 months, which is now 3. I'm at 12.5 mg and supposed to go down another mg. starting tomorrow. Put my back out a week ago and it's still out. Seems like I'm tolerating Ibuprofen with food, which I could not a few months ago. I'm feeding a lot of stuff into my body and I don't like it at all but whatever works. I thought Prednisone was supposed to handle all pain, but it is def not helping my lower back. So Tylenol/IB combo for awhile I guess. All the best with your split dosage. Doesn't hurt to give it a shot. Take care ~ Deb