Amgen makes both drugs and would, of course, prefer if someone took both of them, but a lot of people are opting not to take Prolia. There are choices other than Prolia and reasons people are taking others.

I hope you read the many threads on Mayo Connect dealing with Prolia as there's a lot of information about peoples' experiences with the drug as it's tricky to get off of in case you need to. It might be the best choice anyway or give you questions to discuss with your doctor.

The protocol to go on Prolia is because Amgen owns both Evenity and Prolia! I would think long and hard about going on Prolia because you cannot just stop it. My doc uses Reclast after Evenity and with proper monitoring, says we can even take breaks. He is also considering a partial dose of Reclast depending on results.

Go to the Evenity Amgen site and it says to follow up with Prolia. This is not a "protocol." It is a company suggesting their own drug.

If you cannot take biphosphonates, then Prolia is indeed your only choice.

We can take Evenity after Tymlos or Forteo, but not the other way around- at least not yet. This is apparently because Evenity "turbocharges" bone growth so there is little left for Tymlos or Forteo to do. Now, you do maintenance.

I hope you are able to do Reclast, even a partial dose. Drink a lot of water the day before, of and after the infusion, take tylenol and maybe benadryl. Good luck!