@ajidzior Amy, a couple things. Looks as if you are keeping good records and diaries, so keep it up. Second, sign in to OMIM.org (Online Mendelian.....) Enter by your worst issues, and track their reports. This will not pin down the cause(s), but should give you some ideas. Then do the same with HPO.org, (Human Phenotype.....) Then go to one of the better genetics labs, such as Sequencing.com, Nebula Genetics, GeneDX, etc. and get their report, either of an assay (1% of the whole genome) or a whole genome. Sequencing.com or Ambry Genetics may be the least expensive at the moment. Then, if you can, ask your family for any odd diseases or symptoms such as diabetes, Crohn, Myeloma (most likely), etc. Get a genetics counselor to help you sort it out. There are many Myeloma types which present themselves with the symptoms and signs you name, such as fatigue, tooth pain, eye pain, cardiomyopathy, slow-developing cancers of internal organs, etc. Finally, don't rush too much. And if your doctor is not at least as curious as you about your situation, change doctors. oldkarl