Hey Don. My Mayo dr who has since retired once told me that he has only seen a handful of patients beat mac and that was only after being on antibiotics for 10 years. I have tested negative for Mac since 2014, and had been on monthly maintenance antibiotics for 9 yrs. I was taken off of the monthly rotating antibiotics in Dec of 2021, and now seven months later; I have MAI and aspergillus. The real deal is: although I tested negative for all of those years; the mac is still always with us, it is just at an undetectable level. My going off of the monthly meds was not a good idea, but it was my dr's idea, not mine. I am working on getting back on my prophylactic regimine. I wouldn't stop with the saline either, I got super lax with it, and I feel like that contributed to get this infection again. It is common for patients to get weary of their meds and nebulizing and take vacations from them. It is ok to do that, it just cannot be a very long vacation. Stay smart, and stay well. Hugs!