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Small Fiber Neuropathy biopsy test results

Neuropathy | Last Active: Feb 15 2:46pm | Replies (36)

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@eve38

Hi Joanne,
From my research on Length Dependent and Non Length Dependent small fiber neuropathy, I believe having a positive skin biopsy in the proximal thigh is a more typical presentation in non length dependent sfn. You might want to read about it, and see if your symptoms fit, or not. Non length dependent SFN can be in patches, on the trunk of the body, and on the proximal thigh and arms, and may involve the face, arms, tongue. There may be more itching too. Also it tends to be less symmetrical, rather than the standard stocking and glove expression of length dependent sfn. I have been trying to better understand the symptoms of the two types for myself as I am not sure my symptoms are developing in a classic length dependent fashion.

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Replies to "Hi Joanne, From my research on Length Dependent and Non Length Dependent small fiber neuropathy, I..."

Joanne, I went back and read my biopsy result for SNF. It said that occasionally patients can feel symptoms in the hands first before the lower extremities. I had read elsewhere that length dependent normally starts in the lower extremities and then goes upward. My results also stated that I was not charged for the specimen processing that didn't produce a result. Meaning the one on my lower leg. I have non length dependent SFN. Two days after retiring from my job I woke up with full onset of pinpricks all over. My eyes, face, head arms legs back. All over. If you have ever watched fireflies at night when they light up it reminds me of that. Just one prick right after the other going off. Mine is idiopathic. I didn't have any symptoms of anything so they tested me but nothing came back. I did notice in my left hand from the wrist down to the area between my little and ring finger I had a burning sensation that would come and go all throughout the day. That part has gone away for now. But I have noticed at times that I will have shooting pains in certain areas that will be like across an area of my skin then shooting down. Some of those can be very zap like and sharp. I take alpha lipoic acid daily. I still get the pin pricks whenever they decide to do their thing. They come whenever. Some of the pricks last longer than others. The SNF has affected my heart and it caused my heart rate to accelerate as high as 183 so I take medication for that. I have been taking metoprolol for that and it works but on June 5, I was watching TV and I noticed the same feeling in my chest when it happened before. So I took my heart rate and it only went up to 97 so I took some med. I am now going to have another holter monitor put on this week.

I too have s similar problem. My feet on the bottom I cannot feel. If I put a fan on I can feel the top of feet barely. Also the nuerothapy has reached to my knees and I can only feel with a fan.