@bcool123 I did some research on ketamine but quite expensive and not covered under insurance. It also required hospital stay for patient observation. Now I understand that it can be administered in micro doses. So for me it was not a viable option.

madhouse, I have some more research to do on it too. Thanks for your response. Bcool123

I have been receiving Spravato treatments--esketamine delivered by nasal spray in a controlled setting. Spravato is not an anti-depressant. It is used with patients who have treatment resistant depression. It is helping to alleviate the suicidal thoughts I take an anti-depressant. In 2018, I took the Genesite test. SSRIs such as Zoloft and 30 more are not effective.
Based on the definition of insanity, my docs kept prescribing SSRIs, expecting a different outcome. NOPE.
We found one in a different class for me that is being titrated verrrrry slowly. I'm experiencing positive results. My rule of thumb now is, "Get me off of one creepy feeling medicine before you start another creepy feeling med."
Talk to your doctor.
I come to my appointments with a list of questions, comments, and concerns.
Be your best advocate.
There are lots of comments on the Spravato discussion.
Here's to your health.

@bcool123, I moved your post looking for experiences others have had with ketamine for depression to this existing discussion:
- Has anyone tried Ketamine for depression? https://connect.mayoclinic.org/discussion/has-anyone-tried-ketamine-for-depression/

I did this so that you can read previous comments as well as the responses you've received from @marjou and @audriana.

You may also be interested in this discussion that @audriana started a little while ago too:
- Questions to ask about ketamine infusions https://connect.mayoclinic.org/discussion/questions-to-ask-about-ketamine-infusions/