The article addressed the situation where patients were initially classified as not being surgical candidates. By repurposing an FDA approved drug Losartan, 61% of the study participants were able to have Whipple surgery after treatment-that was the sole purpose of the article and it accomplished its objective.

Here are options for non-resectable patients either because the tumor is in a difficult location such as significant involvement of vasculature or metastatic spread-
https://www.healthline.com/health/inoperable-pancreatic-cancer#diagnosis