I have just ordered some turkey tail mushroom powder to start as a supplement. It was recommended by my oncologist. Going to start slow as I have digestive issues which is the side effect I experience from Letrozole. I really have not had the joint pain. I was just assigned a different oncologist at Mayo in June. She too said we might consider a “vacation”. For the first time in 3 1/2 years she affirmed that my digestive issues could be a side effect. Previous oncologist always said that digestive issues were not a usual side effect and thought it had other causes. Just so reassuring to be acknowledged that it could be a side effect. It does indeed make a difference to have an oncologist that listens.