Have you looked into a mast cell activation issue?? This guide can help you rule in or rule out a mast cell issue. It is written by some of the top doctors in the us on the subject. Once I tested and found a mast cell issues, I began treatment, mostly over the counter meds and supplements, I am much better. I believe my mast cell issues started after 2 very serious infections! Btw, Mayo will not treat mast cell activation syndrome, only to most serious version of mast cell cancers.
https://www.ehlers-danlos.com/wp-content/uploads/MCAS-Primer-for-the-Gastroenterologist.pdf