Welcome @gmaha67. I'm with @jakedduck1 about not leaping to the worst-case scenario. The fact that the Cologuard came back positive can be see as a good thing. Let me explain.

Colorectal cancer grows VERY slowly. It is unlikely that you have developed an advanced stage of cancer in the time between your two Cologuard tests. It is possible that the test picked up on your having benign or possibly pre-cancerous polyps.

As I wrote to @msrhray, getting a positive result from your Cologuard test is worrisome. But try to not worry until further investigations are done. It is possible that the Cologuard result is a false-positive, meaning there is no pre-cancer or cancer present. It may only signify that you have a benign polyp or pre-cancerous polyp. Colon cancer can be stopped in its tracks. It's good that you took the first step for detection.

Polyps are very common. I have had 2 colonoscopies and each time they removed both a benign and a pre-cancerous polyp. I have a colonscopy every 3 years and have never had cancer.

Do you have any questions about preparing for your colonoscopy?