I think Sue's example of a cannon to kill a mouse is great. It is not typical to treat a fever with Prednisone. As a RN have not seen it used in that fashion. Usually it would be used as a systemic anti-inflammatory. It is a wonderful drug and a horrible drug. It does provide great improvement but has side effects that need to be monitored. I wonder if it was prescribed more as an overall anti-inflammatory to treat you? I have bronchiectasis and no MAC (so far) but it does not seem many people on this forum have prednisone as a standard treatment. That would be a good question for your doc.