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Living with Neuropathy - Welcome to the group

Neuropathy | Last Active: 1 day ago | Replies (6021)

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@valleyjunction1942

My name's Richard. I'm 80 years old and I was diagnosed with Type 2 diabetes and hypertension about forty years ago. I started having numbness in my toes and genital area about twenty years ago. In the last five years, I started developing retinopathy. I decided to get as healthy ass possible. I changed my eating lifestyle, lost 114 pounds, and started exercising. I've been doing this for eight years, and my health has rebounded to a surprising degree. The neuropathy in my toes and genitals is receding, and the retinopathy has just recently started to have longer periods without that spot in my right eye that was blurry. I attribute all these changes to better health. I have the notion that the root mechanism behind the neuropathy, microangiopathy, can be made to recede and possibly reversed. I think aerobic exercise helps, but I'm looking for other ways besides diet and exercise. I read a week ago that when people have an MCI, a process called efferocytosis produces two microphages, one of which produces a protein that heals the endothelium. Since the veins and capillaries also have endothelial tissue, I think there might be a way to induce an effercytotic state which would help heal the damage done by diabetes and hypertension. Does anyone else have any info or experience with reversing microangiopathy?

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Replies to "My name's Richard. I'm 80 years old and I was diagnosed with Type 2 diabetes and..."

Hi Richard @valleyjunction1942, Welcome to Connect. Congratulations on making the lifestyle and eating changes to get as healthy as possible. I have made similar changes also to improve my health. The past 2 years I started working on losing more weight and exercising more to improve my health and get rid of my pre-diabetes diagnosis. I also have small fiber peripheral neuropathy with numbness in the feet and legs. I posted my story in another discussion here - https://connect.mayoclinic.org/comment/310341/.

I wasn't familiar with efferocytosis and found this June 2022 article that sounds similar to what you are looking for -- Drugging the efferocytosis process: concepts and opportunities: https://www.nature.com/articles/s41573-022-00470-y.

What started my search into looking at diet and lifestyle more was reading the story of Dr. Terry Wahls who rolled back her MS symptoms through eating changes -- https://terrywahls.com/about/about-terry-wahls/. I also did a little research on the metabolic syndrome and found an interesting video by Dr Jay Wortman - Diabetes Remission is Surprisingly Simple! -- https://www.youtube.com/watch?v=Cx6xw3wOAMc.

I have found that Google Scholar is quite useful when looking for medical research articles.
Have you done any research using Google Scholar - https://scholar.google.com/?