I am new to this site, but started having headaches Feb 2021 that occurred 5-7 days a week, This went on for months. I was tried on the "old standard" meds b/c my insurance would not cover Amovig until I had three "failures" with older treatments. So, tried on triptan which helped stop the HA, but there is a limit of 10 doses per month. Then tried on amlodipine low dose. It helped some, but developed one of the side effects of peripheral edema which resulted in developing Achilles tendinitis, so I had to stop jogging. Then I was tried on topiramate (topomax). I told my newly found neurologist this might be a risky med given my other med conditions of depression and generalized anxiety disorder. His only reply was "you want to get rid of your headaches don't you?" I took it for 7 days and my Migraines increased in frequency and intensity almost immediately. I stopped that med and looked for another neurologist. Finally found a new nurse practitioner who was with a neurology group and specialized in headache related problems for that group.. B/C of 3 med failures and a MRI, I was now approved by insurance for Amovig 70mg sc q28days. My headaches immediately stopped. I was really thankful. The after 3 months in Jan of 2022, my asthma suddenly flared with severe shortness of breath. Over the next 3 months, I was tried on a Prednisone "burst" 2 times with no relief. So found a pulmonology group and was assigned to a nurse practitioner in April 2022. After a series of CT scans and MRI's , she recommened Xolaira . I was hesitant after reading the side effect profile. So went to the Mayo clinic in June 2022 for a 2nd opinion. The senior associate consultant saw me for 5 minutes after the fellow resident completed his exam. One of their conclusions was that this was NOT an asthma related exacerbation. However in the progress notes the fellow resident recommended DULERA be started (a monoclonal antibody similar of Xolara). I never got to have a follow up consult with the "fellow" b/c of a gaff in communication. The clerk left a message at my home land line 400 miles for Mayo. So upon arriving home, realized I had missed my follow up review with the "fellow". He tried to call me a couple times , but I was out running chores. So, I have been essentially be left in limbo. In the meantime, I talked with me wife about where to go from here. We were lost. I researched Amovig and noted that the half life was 28 days and steady state was reached anywhere from 3 to 5 half lives. That matched perfectly with my Amovig. With no where to turn and no guidance, I decided the Lord sent me to Mayo for some reason and that was to find the one bread crumb I needed. So, I did not give myself the June 7th dose of Amovig. Since then my asthma symptoms have improved greatly. Not perfect , but it's only been 10 days. But I am able to return to jogging with no ill effects. Additionally my asthma seems quieted down significantly. Some wheezing intermittently, but nothing like 10 days ago. I am still using Levalbuterol MDI prn before jogging and the Levalbuterol high flow nebulizer twice a day along with Dulera 250 mcg/5mcg 2 puffs twice a day. But my asthma has improved by 30-50%, and even a little greater at times. Since the half life of Amovig is 28 days, it will take another 18 days before 50% of the drug is out of my system. We'll see what happens, but I am hopeful. I am terribly disappointed in the physician follow up at Mayo. Really sad. The gauntlet seems impenetrable. Can't even get an appt with the fellow when I return July 12,13 for a few more tests. However, staff folks were great. Courteous, helpful, polite, and very knowledgeable regarding their jobs (lung tests, blood draws, CT, clerical folks, etc.). So we,ll see how things go. Hopefully, I can avoid Xolara and continue to improve asthma wise. . HA's are starting to return, so not sure how that will play out.. That's my story so far.