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Starting"Big 3": Anyone take Zofran (ondansetron) for nausea?

MAC & Bronchiectasis | Last Active: Jun 17, 2022 | Replies (8)
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@jeannie55

Thanks for your help, Colleen. Thanks, too, for asking how I'm doing.
Day 1 of meds was pretty uneventful. No nausea at all. I think I felt just a "little off", but I'm not sure. I just had bright orange urine, which I had expected.
Today was Day 2 - no MAC meds. But... when I woke up I had a little bit of stomach cramping. It was followed by pretty much all day diarrhea. I think I counted 8 times. I still have no nausea, but off and on have had an achy stomach. I haven't eaten much. I take meds again tomorrow, and I will wait to see what happens the following day. If there's more diarrhea, I'll contact my doctor.

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Replies to "Thanks for your help, Colleen. Thanks, too, for asking how I'm doing. Day 1 of meds..."
ReRE | @jcwest211 | Jun 17, 2022

@jeannie55: I have been taking the Big 3 for over a year. With a negative MAC culture last August, my Infectious Disease doctor reduced the antibiotics to 3 days a week. I tolerated them up until the past month or so when I started feeling nauseous. I found taking them on an empty stomach with a few saltine crackers helps. In addition, eating yogurt and taking a good probiotic is helpful. When you have the diarrhea, try drinking ginger ale or coke in small sips but be sure to flatten them before drinking. It will take some time for your system to adjust to the Big 3.
Also schedule regular bloodwork to check your liver if you are taking Rifampin and schedule eye exams if you are taking ethambutol. Good luck. This is a long journey. Take it one day at a time. Good luck!

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