Hi @jeannie55 - When I was going through chemo, I was prescribed 2 meds for nausea. One was Lorazepam, the other was Zofran. I was instructed to start with the Lorazepam, and to take it at the slightest hint of the onset of nausea. So after my first treatment when I had just a hint of nausea I took the Lorazepam. It did help with the nausea but it also really zapped me out - I basically stayed in bed and slept. When I did get out of bed I was really "out of it" in the words of my adult children. So during my first follow up visit I discussed this with my medical team. They suggested that the next time, I start with Zofran. They assured me that within 20 minutes of taking it, I would have relief from my nausea. So after my second treatment, that's what I did. And like clockwork, 20 minutes later I had no nausea whatsoever. And, I could function just fine, no brain fog, no being "out of it". I am a teacher and continued teaching throughout my treatments. I believe the Zofran helped allow me to do this. For me, it was a lifesaver. But everyone is different. I hope your experience is a positive one!