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@windwalker

Hi Melissa. I am so sorry to hear that Bruce is having such a hard time managing his MAC. Do you have a copy of that susceptibility test and know what meds are listed? When he is on these antibiotics, is it long term?

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Replies to "Hi Melissa. I am so sorry to hear that Bruce is having such a hard time..."

Hi Terri,
The antibiotics are supposed to be long term, 12 to 18 months, although a number of changes and modifications have been made since he started treatment in September 2021. A work in progress.
We do have a copy of the susceptibility tests. Not all of the drugs that Bruce is taking were tested. Oddly Rifampin has the same sensitivity number both times.
The first round of testing was done on a culture from August 2021 and the second on one from March 2022, when he tested positive again for MAC after 3 negatives.
The list includes some drugs with factors of S (Susceptible), I (Intermediate), R (Resistant) :
Drug Test 8/9/21 Test 3/19/22
*Amikacin 16 32
Ciproflaxin 8 >8
Clarithromycin 16 I 2 S
Linezolid 32 R 32 R
Moxifloxacin 4 R 4 R
Rifabutin <=0.25 0.5
*Rifampin 4 4
Streptomycin 64 32

Bruce is on the two starred drugs, Rifampin and Amikacin, the latter of which he takes in a nebulized form (Arikayce). He is also taking Clofazimine and Ethambutol.
Earlier in the week he began the 14 day course of Amoxicillin/Clavulanate (Augmentin) to reduce the suspected Bronchiectasis flare.

Thoughts?
Melissa