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Genetic testing for breast cancer Revised guidelines
Breast Cancer | Last Active: Jul 26, 2022 | Replies (41)Comment receiving replies
This may be a very silly question but, does Oncotype testing apply to metastatic breast cancer patients? I mean, does it only tell you it's likelihood to recur?
I've had a drama on being HER2-negative and then another test showing HER2-positive (albeit very slightly). My treatment is now on HER2-negative. Also, it seems like there's some recent change of understanding on HER2 labeling (HER2 low) which may? affect the treatments for some people.
https://twitter.com/IlanaSchlam/status/1534149465841582084/photo/1
Replies to "This may be a very silly question but, does Oncotype testing apply to metastatic breast cancer..."
The OncotypeDX is used for early estrogen positive breast cancers. But I don't know if it's limited to non-metastatic cancers. And the parent company has other gene tests for other breast cancer questions. The Oncotype customer service is very good and could direct you further. They likely know what other companies are doing as well. It bothers me that not all oncologists are up to speed on what's available. In my opinion, @windyshores and others are amazingly resourceful at finding more help but it's a symptom of a fractured medical system that we have to...the good news being that we can share what we find with each other at least.
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@eku The Oncotype is used at the time of diagnosis, and gives the risk of recurrence, so I don't think it would be used for metastatic breast cancer.
I also had HER2+ then equivocal then negative. But close to the line for positive. As I wrote above, it seems tje ductal part of my cancer was positive and the lobular part was negative. I am going to read what you posted about "low" HER2.
ps here is text on who can use the Oncotype: Oncotype DX helps predict the chance of metastasis and the likelihood of benefit from chemotherapy for early breast cancers that are all of the following [14,32-34]:
Tumor size smaller than 5 cm
ER-positive (and will be treated with hormone therapy)
HER2-negative
Lymph node-negative or 1-3 positive lymph nodes