Gosh, this all sounds so familiar, and the answers should be so easy. However, we live in an age when the easiest answers are usually wrong. However, I would make a couple suggestions. First, You can make great use of a Whole Genome Sequencing, whether covered by insurance or self-paid. There are several great sources, such as Nebula Genetics, Sequencing.com, GeneDX, Ambry, Alnylam, Mayo, etc. Some of the company names change frequently, so start with a good Genetics Counselor. But a whole duck-pond of scam artists will try to scam you for a lot of money if the lab does not follow the rules of Medicare. This will probably not pin-point your disorders entirely, but will give you some great clues. Second, You sound like a form of cancer called Myeloma. There are many types, and almost no one has just one. Me? I have a family with groups of cancer disorders. I have pinned down a large group, so I would not say you have this and not this. I do say, though, that you will almost surely end up with one or more forms of Myeloma, such as Amyloidosis, Gelsolin, as well as some neuro-muscular diseases such as muscular dystrophy. I am not well-versed on environmental issues. The point is easy. Get your Whole Genome, study it thoroughly, It should tell you if you are particularly sensitive to some meds, some bacteria, infections, and some other stuff in your life. Spend some time studying the results. Do not give up easily. oldkarl