Hi @marjou I’m not really sure what the options are for hormone replacement therapy for anyone with the family history of high estrogen. But if a woman’s estrogen is low, and that’s generally what happens at peri-menopause and menopause, I would think if you were given the proper balancing dose just to bring things back in line, that it wouldn’t be any different than having natural estrogen occur.
Which leads me to the question, if you have high estrogen can you be given something to counter that? Just thinking out loud…

I know that back in the late 60s? my mom was prescribed Premarin and was on that for 30+ years without her doctor ever checking on her! Old school doctor dealing with ‘women’s issues’, before we were taken seriously. She ended up with uterine cancer because of the continual building of tissue. In reality, she should have been on a medication for a short while and one such as Prepro which also contains some progesterone.
When I entered peri menopause, my gynecologist pretty much forced me out of the practice when I refused to take artificial hormones because I didn’t want to develop cancer like my mom. I found a very progressive integrative medicine physician (wasn’t called that at the time) and she did a study of my hormones and prescribed a natural plant extract~hormone balancing cream. I’m not kidding when I tell you within the first 1/2 hour after applying about a 1/4 teaspoon of this on my wrist/inside arm that I felt the dark veil of depression lifting! It was the weirdest experience and felt pretty miraculous! I was skeptical but that was the ah ha moment…showed what our hormones can do!
I was on this for less than a year and tapered off. That was 25+ years ago.
There are several good articles online regarding hormones and how they control our thoughts and body that you might find interesting. I posted a few below.
https://www.webmd.com/depression/guide/depression-the-thyroid-and-hormones#:~:text=Because%20of%20biology%2C%20women%20are%20more%20vulnerable%20to,as%20sadness%2C%20irritability%2C%20and%20fatigue%20prior%20to%20menstruation.
https://www.mayoclinic.org/diseases-conditions/depression/in-depth/depression/art-20047725
Have you had your hormone levels checked?