Hello @divinewisdom28 and welcome to Mayo Clinic Connect. Clearly you are feeling something different/off, so it is good you continue to advocate for yourself to get answers.

It seems as though there is a known correlation with jaw pain and Lexapro. See the information below in case this is of help.

"Does jaw pain from Lexapro go away? → Bruxism associated with antidepressant use is an underrecognized phenomenon, particularly among neurologists. → Antidepressant-associated bruxism/jaw pain most commonly begins within 3–4 weeks of medication initiation or dose titration, and can resolve within 3–4 weeks of drug discontinuation."
SSRI-associated bruxism - PMC - NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914744/

Have you heard of the term bruxism? Does this sound like what you are experiencing?

Omg! I was having cardiac stuff, and they said it can be POTS after covid, but first thing they did was lexapro, and now I am feeling the same thing you feel, ENT said there is nothing wrong with my ears ( I cannot pop it), I have pain and numbness on my cheeks and jaw, pain down my neck and also globus sensation ( they think silent reflux is causing it). Have you gotten more answers? I appreciate any help ! I am wearing myself off of the lexapro…

One morning in 2019 after two months on Lexapro, I awoke disoriented, went to the sofa, and sat staring at the floor for about five hours. This repeated the next day. The PCP told me how to get off the drug. The severe onsets continued: dissociation (I was like a camcorder w/o my own identity present), suicidal thoughts ("I'll never get out of this"), totally awake but had absolutely no will power to lift an arm or move, scalp pressure and throbbing, tingling of upper lip and cheeks, jaw included, difficulty speaking. The severity diminished over the years, but the onsets continue even though I have not had the drug in four year. From say the early 90% severity, now it comes on a few days every other week at from 15% to 35%, pulsing head continues, narrow attention focus. I've had all kinds of tests and seen a neurologist twice who insists it couldn't be Lexapro related. I disagree.

My PCP said anti-depressants have nasty side effect. Beware.

I know that this is an old thread, but I'm also looking for some answers here. I started lexapro a few days ago to help manage anxiety. I'm on day 4 and I'm having jaw/cheek numbness on my left side as well. I don't see my doctor again until next week and I'm doing my best not to freak out.

I went to the ER yesterday and all of the tests they ran checked out and they couldn't explain. I mentioned I had started taking Lexapro, but they didn't respond to that at all. AT this point I'm just trying to tough through this until I see my doc.

UPDATE: I reported the tingly feeling and numbness to my doctor yesterday. Their response was "We hear this a lot." and they ordered me to stop taking it immediately. If this is so common, why is this even prescribed?? I'm one day off of it and I still have minor tingles, but no where near as bad as it was yesterday. I'm going to call when my doctor's office opens to see if I need to go to the hospital or what?

It seems no matter what I do; I keep being told to wait to consult with my doctor. My appointment is still a week away 🙁

I have had the numbness occur in my left cheek for many years. It comes and goes. I am currently not on the Pristiq that I took for 10 years and weaned off back in December 2023. I never questioned the sensation since I could deal with that a whole lot better than the debilitating effects of depression. I just find it very weird to read of your experience because this is the first time I've heard it reported by another person. Ironically, I am feeling it now today even though I am no longer taking the meds.

So, I'm now two weeks off of Lexapro and I STILL have the facial numbness and tingling! I called my doctor, and they told me that it could take a while for it to subside. Why is this given to anyone?