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Struggling with making an osteoporosis treatment decision
Osteoporosis & Bone Health | Last Active: Jun 4 11:43pm | Replies (661)Comment receiving replies
but the "gains" from biosphonates is simply the retention of old bone that grows weaker and weaker over time...which is what causes all of those spontaneous femur fractions and jaw necrosis after 3 or more years on those drugs.
Replies to "but the "gains" from biosphonates is simply the retention of old bone that grows weaker and..."
Not necessarily 'after 3 or more years' either. I asked both my PCP and endocrinologist how long one can 'safely' take an anti-resorptive bisphosphonate or Prolia before being at risk for osteonecrosis of the jaw (aka dead jaw bone) and they both answered, 'we don't know.' One study that put participants, who'd taken no previous drugs for osteoporosis, on zolendronic acid, lost one participant to ostenecrosis of the jaw within the first 12 months. That seems to be a rare outcome but the point is that there is no known absolutely osteonecrosis-safe period for these drugs.
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Yes, I posted this on the last page:
"Did your doc say why Prolia was okay after being on Fosamax for a long time? I am curious. They both affect resorption, they both may affect dental issues and atypical fratcures after long term use."
We were discussing medications that are used to follow anabolics (and that anabolics should be used first, since they build quality bone).
I was saying that my doc thinks Reclast is a better follow up than Prolia because it stays in the system longer so there is not the sudden drop off in bone density when stopped. My doc says, therefore, that after Tymlos, Reclast would be better than Prolia because I might be able to take breaks and try more natural methods as long as I am monitored.
It helps to read the whole recent part of the thread!