Given the heterogeneous nature of PCa, there is a Loy of clinical data and personal choice that goes into a decision on if and how long one is on Lupron. In my case, we used triplet therapy, chemotherapy, radiation and a planned 24 months of ADT. We stopped the Lupron after 18 months given my response to the triplet therapy. There were studies pointing to 18 months as being just as effective as 36. The key I think is if the clinical data and your personal preferences support stopping treatment after a specific period and response, you must actively monitor through labs and consults with your medical team and have decision criteria about what constitutes a reason to go back on treatment and a decision point when to do so. For me, that criteria involves labs every 2-4 months, three or more PSA results that showed a continuous rise, PSA above .5, imaging that showed recurrence and then a decision to treat and with what, for how long...I am not a fan of "indefinite...! This chart shows my clinical history, it's been four years off treatment, I have actively monitored my PSA and seen my urologist, haven't met our decision criteria to resume treatment.