Great question. I have been on Lupron for almost one year. The pain in my legs is getting unbearable. I am going to stop the shots. Before taking the Lupron i was able to walk 5 to 7 miles a day without any pain. Most of the time it was on the beach to give my legs a extra workout. Now I am lucky if I can walk half that on a good day. My urologist doesn't want to acknowledge this. In his report he NEVER puts this in there. He also never put in there when I had a rash that started after the first shot and got worse after the second one. Even when i went to dermatologist they said it was probably from the shot. Again he never put it in the report. It makes me wonder as to the reason for this. I have drawn my own conclusion. Wishing you the best.