I was diagnosed with Lupus in my 40s. I quickly realized that no stairs, wider doorways (for walker/wheelchair if I ever needed it), a walk in shower were important considerations. I think, even if I had a beloved home, if it didn't have these attributes I would move. As far as downsizing, square footage is just one aspect. The big thing is to purge the things you no longer use or need and to create a purpose for each room. Having the right things in each room makes life more comfortable and easier, and clutter is easier to avoid. You want things to be simple, easily accessed and fewer objects to keep organized. It is calming. Besides the main bedroom, we have an office (2 desks) and the closet there is His; another bedroom has sewing machine, foldaway bed (I'd rather a day bed in case partner needs to sleep alone) and closet is mine. Living room/dining has table, bookshelves, couch and recliner. Den has TV, stereo, two chairs. I have my favorite wall hangings and pictures up; got rid of the boxes of other frames, etc. I think if we should ever need to transition somewhere else, it will be easier as I have passed on accumulations (including collectibles) of a lifetime. I am working on a book of pictures of people from past generation--scanned and ready to print.