I an 56 year old female. I was diagnosed in 1995 with PPMS. My symptoms at onset were bladder/bowels disfunction, right foot drop, rigidity, spasms, numbness on right side, heat intolerance, depth perception issues, periodically alopecia areata. The past 27 years have been a progression of the same symptoms. In the past year and a half however, things have dramatically changed. I developed bradycardia with no other heart issues, tightness across the chest (MS hug ?), body temperature very seldom 98 degrees (typically between 96.7 and 97.), migraines, dizzy every time I lay flat or get up out of bed. I can walk around without issue but when I stand in one place to do dishes, I get tightness in chest, palpitations, hot feeling, sweaty clammy, if I stand long enough I get vertigo and one time I lost consciousness. The fatigue is now sometimes so extreme. I have been to cardiology and my neurologist. My next appointment is with endocrinology. So far, it is appearing to be MSA. I am devastated and terrified. Is there anyone else experiencing this too?