Hello. I know this is four years after your initial post, but I know people will still have the same question you posed. I took Effexor for a good 20 years. It took me 2 years to wean off slowly. My last dose was a month ago. Now, as I was weaning off, my generalized anxiety started to rise. I have no depression, but the anxiety is certainly there. Covid and being unemployed haven't helped, of course. But the main thing I've developed is incredible fatigue. There's no reason for it. I'm healthy and have no underlying conditions, but I can barely move. I do not know why, and neither does my doctor. It's also incredibly hard to find a doctor who understands the effects on the body when getting off long-term Effexor. This Mayo Connect has helped me more than most doctors. Has anyone else gotten the insane fatigue after coming off long-term Effexor?