Hi @colleenyoung. Thank you for your response. I actually started the anastrozole Sunday night. Monday I woke up with red, irritated /dry eyes, and chills. By 10 a.m. I could not get enough to drink so needless to say I was in the bathroom a lot. My hands were pruny, and my sinuses were dried out, by the evening my hip and lower back had started to ache. My husband took one look at me and said I was dehydrated( and I had increased my fluid intake!) I called the pharmacist who told me to contact my doctor which I did Tuesday morning. I did not take another pill and by Tuesday night I started to feel better. Thursday morning I finally got a call back from the doctor's office and was told that my side effects happen in less than 5% of people and it was really unusual that it happened all at once. I was made to feel like an idiot and that I was crazy. They said I could continue to take or not just let them know. If I do start again I will try again this Sunday, I have to do some errands tomorrow and need to be able to do them. Before I had started taking I had also asked about a baseline bone density test and taking Vitamin D and they said not necessary. I feel foolish. My surgeon sent me to this oncologist, not sure if I need to let them know what is going on and possibly go elsewhere. Do AIs really help decrease BC chances with ADH? Thank you in advance.