I’m not sure what you’re asking about B6? Here’s from online, “While vitamin B1 acts as a site-directed antioxidant, vitamin B6 balances nerve metabolism, and vitamin B12 maintains myelin sheaths.” I read that an artificial B vitamin called NAC was scientifically proven to work better than B vitamins. I couldn’t find NAC by itself in Walmart but, I found a product called Nervine that contains NAC which I began taking. I read mixed reviews about Nervine, some it did nothing for; others it took a few weeks but their neuropathy subsided. After I finished a 30 day supply the nerve pain was pretty much gone so, I didn’t buy more. Then my doctor gave me a B-12 vitamin shot. I was also taking a lot of other vitamins and began consuming copious amounts of leafy green veggies in smoothies, eating more salads and veggies, quit caffiene, sugar, etc. By the time that I got into the rheumatologist for my RA, the neuropathy was already gone.