Long term low doses of Prednisone reduce your ability to make and use antibodies. So in a sense we are immunocompromised after using long term prednisone. Evusheld is a monoclonal antibody that can be given in two shots in an infusion center that provides the patient with antibodies to Covid. Lasts maybe 6 months. It just brings you up to the level of a person with covid vaccinations and boosters. You have a chance of being protected from serious consequences. Not totally from infection.