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Unusual side effect of Rifampin

MAC & Bronchiectasis | Last Active: May 6, 2022 | Replies (18)
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@crepass

I was just taken off rifampin due to low platelets and petechiae and bleeding. I went off all 3 antibiotics for 2-3 weeks. My ID doctor wants me back on just azithromycin and ethambutol now. I feel like I&m having a return of night sweats and culls and cough so probably will do as she suggests and start back on 2. Has anyone had any experience with this plan of action?

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Replies to "I was just taken off rifampin due to low platelets and petechiae and bleeding. I went..."
Sue, Volunteer Mentor | @sueinmn | May 5, 2022

I have not specifically seen your bleeding issues, but I had a very hard time with Rifampin, starting and stopping several times during treatment in 2018/2019 due to nausea and other effects. Now I have learned that the dosage probably should have been adjusted when I was using it daily.
According to my ID doc, there is still a lot of discussion as to whether it really adds enough to the effectiveness of MAC treatment to offset the numerous side effects, If I ever need to go back to antibiotics, I am likely to request an alternative to rifampin.
Sue

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