Just discovered this great resource. Over the past 12 years I have gone from 105 lbs to 190. Before this I was always around 103-110 (even after two pregnancies).

I started seeing doctors 10 years ago when at 115 because I knew it was not normal. No doctor has been able to diagnose. Now I have many other problems including diabetes, have very little stamina and can't even walk a block without shortness of breath. I used to run 20 miles a week and bike ... but my whole personal and professional lives are horrible now ... can't even make it to programs and meetings because I don't feel well.

I've done many blood tests of all sorts over the years and several MRI of pituitary and adrenal.

Now, I am exhibiting all the symptoms associated with Cushings Syndrome except the 24 hour urine cortisol test. While I do show small adenoma on pituitary and all the symptoms, they don't think its Cushings related due to the 24 hour urine cortisol coming back 'normal.' I've done saliva test and morning is 'in range' but night time and afternoon are high. The suppression test is also coming back 'normal.'

One thing I do know is that I don't sleep well. But 85 lbs due to poor sleep?

One observation I have shared with the doctors (but they continue to disregard it but worth mentioning) is that for 1.5 years 13 years ago I took Ativan which caused a huge weight loss (but had severe negative side effects including delirium and retrograde amnesia). It might be a clue, however, that research has shown in some patients it lowers cortisol levels. I took it 3 times more a few years ago (each time only for 3 days or so when close family members passed away and each time I exhibited all the same symptoms including huge weight loss). So, this may be just coincidental or may be a clue.

I've seen doctors at Stanford and UCSF, but none really listen and keep repeating the same tests over and over again.

So now, 12 years later I've gone from an active person to basically one who can't even walk a block. At 50 I was in best shape I had ever been and now at 60, well.

I am a moderate eater, Mediterranean diet.