I lasted 6 weeks on the big three. I was treated by a pulmonary doc but I don't feel he knew much about MAC and the different options on how to take the meds. He never even brought up the option of airway clearance. The most hurtful thing about it all was that he never offered to refer me to another doctor--pulmonary or infectious disease specialist. It was through this forum that I was guided to a doctor who knew how to move me forward. I've been on this trek for close to 3 years--with Pseudomonas being my primary problem. Otherwise just doing airway clearance and keeping my doctor informed of any changes I see in my symptoms so he can make any needed adjustments. I say keep reading, learning and reaching out for help. You'll find what works best for you. God bless you. Faye