Americans take ten times more prescription drugs then other Industrialized countries. The medicine I was taking, Anastrozole, gave me bad side effects, after being on the medicine for more then 2 months. It made me so irritable and mean it would have destroyed my marriage and my relationships with family and children. This POST is probably the effects of the Anastrozole still in my system. It was affecting my mental health that I started to drink alcohol, eat tons of carbs, and sugar. I was gaining weight and felt depressed. They offered anti-depressants or mood stabilizers, to combat the side effects. I have never been on anti-depressants. America has 5 percent of the worlds population but uses 60 percent of the worlds anti-depressant medicine. When I went off this medicine I feel like a million dollars, stopped drinking alcohol, started eating healthy, etc.. Maybe, in my case, the Anastrozole is doing more harm then good? I will try another estrogen blocking drug but this would be my 3rd drug. Most important I trust my doctor and team at Mayo.