Thanks. So in a sense the tests are measuring different things as well. Or different things at different stages.

For what it's worth, I would likely have done what you did because of the LVI.

I do think it's interesting that Oncotype's website gives examples of scores which purely clinical evaluation might have seen differently. The patient with a large, stage 4 tumor and lymph involvement and low risk according to the test at least. And a patient with a grade 0, clean lymph biopsy but a risk for recurrence of 50+% according to the test.

That certainly seems counter-intuitive and, for the grade 0 patient, might have yielded a more-attentive post-surgical follow-through since some doctors are considering grade 0 almost a pre-cancer.

For what it's worth, the science guy I talked to at Oncotype said that, from what they see, the grade 0 specimens being submitted to them 'are definitely cancer' and his inference was that the medical community might be underestimating their seriousness.