@chronicpaincanada What are your diagnoses? Do you mind sharing what your daily routine looks like? How about what small sliver of joy you manage to find? It is helpful if you share a little more about yourself so other members may chime in with suggestions. Most importantly I want you to know that there is hope, if you open your mind to hope. What motivates you to be in a better place?

So sorry for your problem. I can sympathize because I had pain that lasted for many years. Thankfully it is now under control with medication. Your journey seems daunting. I do believe that if you keep searching you will stumble upon the right answers.

Geez, @chronicpaincanada, That is a rough one. I know, because I have had much of the same crap. However, a few years ago I was started by a smart doctor down the path of genetic searching. I was so naive genetically I did not have any idea that I had myeloma (a form of Cancer) all over my body, and that it was mutating into Amyloidosis, Gelsolin and some others. I was too cheap to spring for the whole genome analysis, however, so The answers came slowly. But now I am getting the whole thing from Nebula. But I have learned I have a snoot-full of disorders and diseases and syndromes, each of which has its own dirty linen. Anyway, tell your doc to not be so greedy that they cannot help you get the answers which are probably found in a whole genome analysis from one of the better labs, such as Nebula, GeneDX, Sequencing.com, etc. Then talk with a genetic counselor about what it means. oldkarl