The glycopyrrolate worked pretty much immediately but it works by decreasing saliva production so one also needs to drink enough water to remain hydrated. I just took it at night when the constant feeling that I needed to swallow was annoying and the constant swallowing triggered a sore throat. And swallowing didn't even help as, within a minute, I'd have the same level of saliva anyway. The gastroenterologist used a toilet tank analogy, the salivary glands were sensing inadequate saliva (needed to rebalance oral biome) and just made more. It was oddly maddening and took overma year to, very slowly, abate. I alsom discontinued famotedine and omeprazole in case they were somehow contributing to the cycle. Oh, it was also worse when lying down lending credence to the gastroenterologist's suspicion it could be GI tract related.