@daliea, I moved your question about SVT and medications to this existing discussion.
- SVT Medications https://connect.mayoclinic.org/discussion/svt-medications/

I did this so you could read past suggestions by members and connect with others like @ajnewyork @predictable @lisadib and @bjanderson.

Genetic testing or pharmacogenomics has great promise and has made important strides in recent years. While pharmacogenomics is still in its early stages, progress in this field points toward a time when pharmacogenomics will be part of routine medical care — at least for some drugs. https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/personalized-medicine/art-20044300

@daliea, what led to your getting genetic testing to discover that you metabolize some drugs poorly?

Hi @daliea, I'm not sure I have experiences you'd find valuable, although it's possible that my gene tests are slightly relevant. For context, my main problems are AFib, hypertension, and related kidney disease. The nucleus of the diseases is my high blood pressure that was studied, diagnosed, and treated by Nephrology rather than Cardiology. Gene testing was useful for exploring a kidney cyst and checking for excess aldosterone from my associated adrenal glands, but pivotal in identifying potassium deficiency as a basic cause of my blood pressure problem.

One cause of that hypokalemia was the Liddle Syndrome, an inherited mutation of kidney tissues that fails to recover potassium from urine as it is withdrawn by the kidneys from the blood. As a result, my diuretic is an offbeat variety, Amiloride, which preserves potassium. Eating potassium-rich foods rounds out my therapy for that problem.

In contrast, genetic tests established that neither my kidney cyst nor excess aldosterone were attributable to my heritage, and that simplified my medicinals greatly. My AFib may be a result of hypertension, but that seems speculative without genetic information to prove it, so my main medicine is Coumadin (Warfarin), an anticoagulant for preventing formation of blood blots within an atrium of my heart. That failed me once, and I suffered a "small stroke" that has caused minor problems with physical balance and sensory functions, but no other conscious symptoms of heart dysfunction.

This calming of my heart beat may be attributable to Carvedilol, a beta blocker that slows and eases heart beats and widens arteries to improve blood flow. Like you, my wife encountered SV tachycardia some years ago and has dealt with it with Atenolol, another beta blocker; it has essentially eliminated incidents of accelerated heart rate. Martin