Thanks so much Sue for sharing your experience. I'm happy for you and your husband, and admiring of his -- and your -- perseverance through what clearly were difficult times. I have had 5 gemcitabine infusions, with one more to go. None of them were painful. My bladder did not have to go through the trials your husband's did. Following nos. 4 and 5, I had sudden tiredness and pressure/brain fog/wooziness especially after no. 5. That was of some concern to me. My 6th is scheduled for 4/18. My worry was about the possibility of symptoms similar to what I'd had, but permanent. My hunch is that's unlikely. Continued good luck to you and your resilient spouse.