Morning, I was on two 0.5 which I could take anytime of day but I mostly took both at bedtime. In my past post naturopathic doctor. I cut down to one pill and half of the second for 90 days. Im still doing the same. No side effects but don’t feel ready to cut back to just one yet. She advised a lot of B vitamins which I take still. I’ll take as long as it takes, it’s not a race. You need assistance to help you. Im doing it a half a pill at a time. So far so good. Good luck..Joanne