Hi Coleen, thank you for your reply. I have read side effects to Depakote and may have more than just tremors, trembling, twitching, etc. I have been on it for about 10 yrs and it seems I’m having worsening tremors and many of these side effects throughout the yrs. I am a Reiki Master and do meditation which helps. I am now having difficulty swallowing and stomach issues so I hope my visit to Mayo can help resolve some of my issues or at least help. I have not heard about the Pain Rehab Center but will look into it before my appointment.