Welcome @tarheel22, I'm sorry to hear your pain is making your daily living more difficult. @steve1960 has posted about taking Desvenlafaxine (Pristiq) in another discussion here - https://connect.mayoclinic.org/discussion/pain-and-stiff-neck-with-pristiq/. I'm not sure @steve1960 is still following the discussion but may be able to share their experience with you.

I wasn't able to find other members who have mentioned the drug helping with neuropathy but I did see this 2017 article on the topic that you might find helpful --- Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor: https://pubmed.ncbi.nlm.nih.gov/28229443/

The Foundation for Peripheral Neuropathy has some information on different types of treatments for neuropathy that you might also find helpful - https://www.foundationforpn.org/treatments/.

Have you done any research into complementary or alternative treatments for neuropathy?