Connect
← Return to Has anyone tried anti-depressant medication for neuropathic pain?
Discussion
Has anyone tried anti-depressant medication for neuropathic pain?
Neuropathy | Last Active: Dec 8, 2022 | Replies (107)Comment receiving replies
I have had painful neuropathy in my hands and arms for over two years. I had two spinal fusions in 2019 and the pains have gotten progressively worse since the surgeries. I have been on Lyrica, Cymbalta and Methadone but pains continue and increasingly effectiving my daily living. Based on some genetic tests, my doctor is titrating me off of Cymbalta and will replace with Desvenlafaxine. Has anyone had experience with Desvenlafaxine treating chronic neuropathy?
Replies to "I have had painful neuropathy in my hands and arms for over two years. I had..."
Worked somewhat. But did not eliminate the pain.
I have been on venaflaxine and it was good. Trying to get back on it next week.
Connect
Welcome @tarheel22, I'm sorry to hear your pain is making your daily living more difficult. @steve1960 has posted about taking Desvenlafaxine (Pristiq) in another discussion here - https://connect.mayoclinic.org/discussion/pain-and-stiff-neck-with-pristiq/. I'm not sure @steve1960 is still following the discussion but may be able to share their experience with you.
I wasn't able to find other members who have mentioned the drug helping with neuropathy but I did see this 2017 article on the topic that you might find helpful --- Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor: https://pubmed.ncbi.nlm.nih.gov/28229443/
The Foundation for Peripheral Neuropathy has some information on different types of treatments for neuropathy that you might also find helpful - https://www.foundationforpn.org/treatments/.
Have you done any research into complementary or alternative treatments for neuropathy?