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What problems have you had with Tamoxifen?

Breast Cancer | Last Active: Jan 25, 2023 | Replies (67)

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@colleenyoung

Several of you have mentioned breast cancer biomarker testing, like Oncotype. There are several discussions on Connect talking about this testing, for example:
- How did you decide on breast cancer treatment based on Oncotype? https://connect.mayoclinic.org/discussion/oncotype-result/

@shortie0650 I found this information about biomarker testing in Alberta, Canada. Alberta Health Services started funding OncotypeDx™ in 2014.
https://www.albertahealthservices.ca/assets/wf/lab/wf-lab-bulletin-odx-testing-in-alberta.pdf

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Replies to "Several of you have mentioned breast cancer biomarker testing, like Oncotype. There are several discussions on..."

Oncotype DX testing is not available for those with HER2 Positive receptor, which I have. I wish it were. I am on Herceptin (3 months now) which is the only treatment for HER2 Positive breast cancer. Herceptin has caused severe lower back pain and stiffening, along with the usual fatigue, nausea, headache, G.I. issues. My echocardiograms are showing worsening side effects to my heart.

Regarding Tamoxifen, after two weeks I experienced severe nausea and abdominal cramps. I went off Tamoxifen and am considering stopping Herceptin.

Would love to hear others' experiences. Thank you!