Hello @drigg97, welcome to Connect. Yes indeed, I have had these kind of symptoms together. I'm sorry for what you have been experiencing. Your poor central nervous system is in an uproar. You have had quite a bit happening in just 4 months, you must be exhausted.

I noticed you have also posted in the Neuropathy group which is where I started on Connect a few years back, having Small Fiber Neuropathy. I'm happy to know you are scheduled for a skin biopsy in May. It's best to rule out possible cause. Here, you can find other members neuropathy journeys:

- Member Neuropathy Journey Stories: What's Yours?: https://connect.mayoclinic.org/discussion/member-neuoropathy-journey-stories-whats-yours/

While we wait for members to respond, I will share this video from Mayo Clinic's Dr. Sletten presenting on Central Sensitization Syndrome (CSS):

I have CSS. It is what tied all my "stuff" together after many years of uncertainty. Having such a wide array of symptoms, or "popcorn symptoms" as Dr. Sletten calls it, is without a doubt taxing physically and emotionally. It's good to learn as much as you can as you continue to navigate further.

You're still early in the game of diagnosing and attempting to find treatments that work. I hope prednisone infusions bring you relief. I greatly understand the toll this all takes on a person and their family. Please keep hope alive!

Do you mind letting me know your thoughts on the video and if it resonates with you? I am here to help with any questions you may have.