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What problems have you had with Tamoxifen?

Breast Cancer | Last Active: Jan 25, 2023 | Replies (67)

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@callalloo

It's a lot easier if one had any of the genetic tests that use analysis of genes (including looking for well- and lesser-known genetic mutations that signify possible quixotic reactions to cancer) that yield a risk score for recurrence. I had the OncotypeDX done and it changed the breast surgeon's and oncologists outlook for treatment as the risk score was low.

Oncotype's website shows a few examples where clinicians might have predicted differently: a client with Stage 0 non-invasive DCIS but a genetically-based recurrence risk of over 50% and a Stage 4 invasive DCIS with lymph node involvement but yielded a low risk from genetic testing. So, what might sound bad using the usual statistical models, might not have a negative outlook and vice versa.

But people can try the anti-hormone drugs and monitor side effects, if any. Just be aware of the drug's risk profile and which side effects might actually be symptoms of a problem. Every drug has a risk profile. The newest drugs have the least data so my preference is to not take any or proceed either care if one is necessary. Be extra body-attentive in a sense.

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Replies to "It's a lot easier if one had any of the genetic tests that use analysis of..."

I have a telephone appointment for genetic testing on May 16 (to get the ball rolling). My sister had the genetic testing done - it cost her over $6000.00 and they suggested two drugs that would work with her type of cancer. One was only available in the US and we live in Canada. The other had to be on a recommendation of the oncologist. Her oncologist kept making up excuses about why she would not apply for it - I think it was because she was 77 years old and was discriminated against. But is is a moot point now because she died last Friday - one week ago today! So I'll see what the genetic testing says, but I am a bit jaded at the moment!