Hello, @lou277. Do you know the type of endometrial cancer you were diagnosed with. Is it clear cell carcinoma? Since you had trouble breathing during or after the one round of chemotherapy and they know that now is your doctor thinking they will use a different chemotherapy? Or perhaps give you medicine so that your breathing will be stable during the chemo?

We (including myself) are not medical experts here on Mayo Clinic Connect so I can't say why your doctor wants you to have chemo. I do know that Grade 3 is a high grade carcinoma like you wrote so I'm thinking that the additional treatment beyond the hysterectomy is recommended for this reason. Unless you can get a second opinion within the next week it seems like your doctor does not want you to wait on this. Still, it is always your choice of what you want to do.

Did you ask your doctor the question you are asking here? If I'm Stage 1a, Grade 3 why do I need chemo? It's a good question to ask and I hope your doctor or the cancer team will take the time to answer this question and others you have.

Won't you please come back here and tell me what your doctor says and what you decide to do?

Lou, did you get another chemo treatment this past week? Have you sought a second opinion?

I hope you've been able to get a second opinion since you've posted. I wanted to say that I, too, had an allergic (?) reaction to my first chemo treatment, and it was a lot: suddenly there were six people in the room! I felt my throat tingle, itch, then start to close up, but I was warned about those possible symptoms so I was able to tell them it was happening. They stopped the infusion, then re-started it (which is the protocol). I continued with my prescribed chemo, but over the course of the six treatments, it was reduced a few times. And it was still brutal, something I'm sure many can attest to. I hope you've been able to get some answers, as well as some reassurance. Best wishes.