Clearly Prolia and biphosphonates help in preventing bone loss when on aromatase inhibitors (though I did not go on them based on doc's concerns about other conditions). Clearly they are also helpful when dealing with recurrence/spread in terms of preventing pain and fractures. The remaining question is what role they might play in preventing recurrence or spread. If that was found to be true 20 years ago, that research would still be valid unless disproven! I have a copy of one study in a folder somewhere that was pretty convincing, but cannot find it online. I'll post it if I find it.