Hi @leeann66 thanks for reaching out to the community. I am hoping others will chime in here. But I thought I would share that I have taken prednisone with treatments to prevent some of the hardest side effects, my husband who has myeloma gets prescribed dexamethasone with a couple of his types of treatments for the same reason. None of us love steroids but it does seem to help us stay on track with our treatments when our body wants to say no. I am praying this goes well for you and you can stay on track, or they decide on a better treatment. After afinitor does the doctor have another targeted tool in the box for you?