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What problems have you had with Tamoxifen?

Breast Cancer | Last Active: Jan 25, 2023 | Replies (67)

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@callalloo

As you point out, people's tolerance differs. I asked my oncologist about tamoxifen as an anastrozole substitute and he was opposed to it because of the DVT and less-likely ovarian cancer risks. And he likes Evista less,

I'm looking at osteoporosis treatments and the choices are either of dubious effectiveness (the older bisphosphonates) or side effects I hope to avoid but am getting ducks in a row just in case. My only current strategy is to hope diet, exercise and the vibration therapy stuff preclude ever needing to take any. The actress Bette Davis said "getting older ain't for sissies" in some televised interview my mother used to like to quote with a laugh when a new body ache showed up. Now I find that wry observation a tad more relevant, alas.

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Replies to "As you point out, people's tolerance differs. I asked my oncologist about tamoxifen as an anastrozole..."

From a Marnie Clark recent email regarding Professor Jane Plant, a British geochemist who struggled with recurrent breast cancer: "Prof Plant’s breast cancer did recur in 2011, and she believes that there were several reasons it did. She had slipped off her strict diet, and she was under a lot of stress writing a new academic book. So she went back on her strict diet, incorporated more exercise into her routine, and began meditation. She also took tamoxifen. Sadly, Prof Plant is no longer with us but she didn't, apparently, die from breast cancer. She died in 2016 from a blood clot, more than likely caused by the tamoxifen she was taking." Jane Plant's book about her BC and diet is Your Life in Your Hands. This is not to imply that post-menopausal tamoxifen takers will have DVT or ovarian/endometrial cancer. They say the risk is low, but to me scary nonetheless. I too am doing what I can to preserve my bones, mainly supplements, diet, and exercise.